RIFM fragrance ingredient safety assessment, 2-butanone, CAS Registry Number 78-93-3. (December 2019)

• Record Type: Journal Article
• Authors: Api, A.M.; Belmonte, F.; Belsito, D.; Biserta, S.; Botelho, D.; Bruze, M.; Burton, G.A.; Buschmann, J.; Cancellieri, M.A.; Dagli, M.L.; Date, M.; Dekant, W.; Deodhar, C.; Fryer, A.D.; Gadhia, S.; Jones, L.; Joshi, K.; Lapczynski, A.; Lavelle, M.; Liebler, D.C.; Na, M.; O'Brien, D.; Patel, A.; Penning, T.M.; Ritacco, G.; Rodriguez-Ropero, F.; Romine, J.; Sadekar, N.; Salvito, D.; Schultz, T.W.; Siddiqi, F.; Sipes, I.G.; Sullivan, G.; Thakkar, Y.; Tokura, Y.; Tsang, S.;
• Is Part Of: Food and chemical toxicology. Volume 134(2019)Supplement 2
• Publication Date: 2019-12
• Subjects: Genotoxicity -- Repeated dose, developmental, and reproductive toxicity -- Skin sensitization -- Phototoxicity/photoallergenicity -- Local respiratory toxicity -- Environmental safety; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2019.111025
• Languages: English
• ISSNs: 0278-6915

Abstract

Highlights: 2-Butanone; a safety assessment based on RIFM's criteria. A safety assessment based on 7 human health endpoints plus environmental. All endpoints were cleared using target data, read-across, and/or TTC.