Acute embryonic exposure of zebrafish to permethrin induces behavioral changes related to anxiety and aggressiveness in adulthood. (February 2020)

• Record Type: Journal Article
• Authors: Nunes, M.E.M.; Schimith, L.E.; Costa-Silva, D.G.; Leandro, L.P.; Martins, I.K.; De Mello, R.S.; Nunes, F.V.M.; Santer, M.; Vieira, P.B.; Posser, T.; Franco, J.L.
• Is Part Of: Journal of psychiatric research. Volume 121(2020)
• Page Start: 91
• Page End: 100
• Publication Date: 2020-02
• Subjects: Neuroscience -- Fear -- Anxiety -- Aggressiveness -- Pyrethroids; Psychiatry -- Periodicals; Mental Disorders -- Periodicals; Maladies mentales -- Périodiques; Psychiatry; Electronic journals; Periodicals; 616.89005
• DOI: 10.1016/j.jpsychires.2019.11.006
• Languages: English
• ISSNs: 0022-3956

Abstract

Abstract: Permethrin (PM) is one of the most used synthetic pyrethroid worldwide. Exposure to this compound during pregnancy and early childhood has been indicated as a risk factor for neurodevelopmental disorders. We evaluated the long-term effects of embryonic PM exposure in different stages of zebrafish development. Briefly, embryos (3 hpf) were exposed to sub-lethal concentrations of PM (25 and 50 μg.L −1 ) during 24 h and then behavioral parameters were evaluated during embryonic (28 hpf), eleutheroembryonic (3 dpf), larval (7 dpf), and adult stages (90 dpf). PM exposure decreased spontaneous movement at 28 hpf and decreased thigmotaxis in eleutheroembryos. The long-term effects of PM include changes in non-motor behaviors such as fear and anxiety in larva and adults. Adults embryonically exposed to PM also showed a significant increase in aggressiveness parameters. These results demonstrated that embryonic exposure to PM induces persistent neurotoxic effects in adulthood, which can impair the cognitive and behavioral fitness of non-target species contributing to a rise in neurodevelopmental disorders.