Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor. (January 2020)

• Record Type: Journal Article
• Authors: Li, Bao-Hua; Garstka, Malgorzata A.; Li, Zong-Fang
• Is Part Of: Molecular immunology. Volume 117(2020:Jan.)
• Page Start: 201
• Page End: 215
• Publication Date: 2020-01
• Subjects: DC dendritic cell -- HCC hepatocellular carcinoma -- HIF hypoxia-inducible factor -- LLC Lewis lung carcinoma -- MDSC myeloid-derived suppressor cell -- M-MDSCs monocytic MDSCs -- Mϕs macrophages -- NK natural killer -- PMN-MDSCs polymorphonuclear MDSCs -- ROS reactive oxygen species -- TB tumor-bearing; MDSCs -- Chemo-attractant cytokines -- Tumor microenvironment -- Immunosuppression -- Therapeutic targeting -- Cancer immunotherapy; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2019.11.014
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: We describe the chemokines and their receptors, including CCL2/CCL12-CCR2, CCL3/4/5-CCR5, CCL15-CCR1, CX3CL1/CCL26-CX3CR1, CXCL5/2/1-CXCR2, CXCL8-CXCR1/2, CCL21-CCR7, CXCL13-CXCR5 axes important for MDSCs recruitment to the tumor site, and their correlation with tumor growth, metastasis and prognosis. We discuss underlying signaling pathways and regulatory mechanisms involved in the chemokine control of MDSCs migration to the tumor site. We examine chemokine and their receptors as a potential targets in cancer immunotherapy, solo or in combination therapy. Abstract: Myeloid-derived suppressor cells (MDSCs) expand in tumor-bearing host. They suppress anti-tumor immune response and promote tumor growth. Chemokines play a vital role in recruiting MDSCs into tumor tissue. They can also induce the generation of MDSCs in the bone marrow, maintain their suppressive activity, and promote their proliferation and differentiation. Here, we review CCL2/CCL12-CCR2, CCL3/4/5-CCR5, CCL15-CCR1, CX3CL1/CCL26-CX3CR1, CXCL5/2/1-CXCR2, CXCL8-CXCR1/2, CCL21-CCR7, CXCL13-CXCR5 signaling pathways, their role in MDSCs recruitment to tumor tissue, and their correlation with tumor development, metastasis and prognosis. Targeting chemokines and their receptors may serve as a promising strategy in immunotherapy, especially combined with other strategies such as chemotherapy, cyclin-dependent kinase or immune checkpoints inhibitors.