A case of pulmonary tumor thrombotic microangiopathy associated with lung cancer diagnosed by cell-block immunohistochemistry of pulmonary microvascular cytology. (2019)

• Record Type: Journal Article
• Authors: Yamakawa, Hideaki; Oba, Tomohiro; Ohta, Hiroki; Tsukahara, Yuta; Kida, Gen; Tsumiyama, Emiri; Nishizawa, Tomotaka; Kawabe, Rie; Sato, Shintaro; Akasaka, Keiichi; Amano, Masako; Kuwano, Kazuyoshi; Matsushima, Hidekazu
• Is Part Of: Respiratory medicine case reports. Volume 28(2019)
• Publication Date: 2019
• Subjects: Pulmonary tumor thrombotic microangiopathy -- Pulmonary microvascular cytology -- Cell block technique; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2019.100956
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: Pulmonary tumor thrombotic microangiopathy (PTTM) is rare but should be considered as a possible diagnosis in patients with cancer. In this case, PTTM induced by lung cancer was more accurately diagnosed using cell block immunohistochemistry of pulmonary microvascular cytology (PMC) because we could confirm that lung adenocarcinoma was the origin of PTTM by the positive result of TTF-1 for atypical cells in PMC. The PMC procedure was minimally invasive and safer than lung biopsy. We believe that the cell block technique of PMC should be considered as one diagnostic option in PTTM.