Non-invasive oral cancer detection from saliva using zinc oxide–reduced graphene oxide nanocomposite based bioelectrode. (December 2019)

• Record Type: Journal Article
• Authors: Verma, Shilpi; Singh, Surinder P.
• Is Part Of: MRS communications. Volume 9:Number 4(2019)
• Page Start: 1227
• Page End: 1234
• Publication Date: 2019-12
• Subjects: Materials -- Periodicals; 620.11
• DOI: 10.1557/mrc.2019.138
• Languages: English
• ISSNs: 2159-6859

Abstract

Abstract: Abstract : Multifunctional materials with excellent biocompatibility and electron-transport properties are critical for the pursuit of point-of-care biosensing devices. The authors report the synthesis of zinc oxide–reduced graphene oxide (ZnO–rGO) nanocomposite for the fabrication of an electrochemical immunosensing test-bed for noninvasive onsite detection of oral cancer biomarker (interleukin-8, IL8). The immunosensor showed successful detection of IL8 at low concentration ranges, i.e., 100 fg/mL–5 ng/mL with a sensitivity of 12.46 ± 0.82 µA mL/ng and a detection limit of 51.53 ± 0.43 pg/mL. These results have been validated through in vitro investigations using real saliva samples spiked with IL8.