More or less – the same? mRNA fluctuations are balanced during translation. (22nd October 2019)

• Record Type: Journal Article
• Authors: Kozlovski, Itamar; Agami, Reuven
• Is Part Of: EMBO journal. Volume 38:Number 23(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-10-22
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.2019103651
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : Transcription factors have been traditionally studied at the level of transcription, neglecting a potential impact on protein translation. A new study published by Lorent et al (2019) describes a mechanism by which fluctuations in mRNA abundance are counteracted during translation upon estrogen receptor‐alpha (ERα) depletion. This phenomenon, termed translational offsetting, is prevalent and programmed to maintain essential proteins at constant levels. Abstract : Analysis of estrogen receptor alpha signalling reveals an underappreciated capacity of the translation process to adjust the proteome in response to mRNA fluctuations.