Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome. (20th November 2019)

• Record Type: Journal Article
• Authors: Ahamad, Javed; Toufeeq, Ibrahim; Khan, Mohammad Ahmed; Ameen, Muath Sh. Mohammed; Anwer, Esra T.; Uthirapathy, Subha; Mir, Showkat R.; Ahmad, Javed
• Is Part Of: Phytotherapy research. Volume 33:Number 12(2019)
• Page Start: 3112
• Page End: 3128
• Publication Date: 2019-11-20
• Subjects: diabetes -- cardiovascular disease -- chemistry -- metabolic syndrome -- obesity -- Olea europaea L -- oleuropein; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.6511
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : Olive ( Olea europaea Linn., Fam. Oleaceae) is commonly known as Zaytoon in Mediterranean region. Its fruits and oil are essential components of Mediterranean diets. Olive tree is a prevalent plant species and one of the important cultivated crops of Mediterranean region. Oleuropein is a phenolic constituents of olive, which, along with its related compounds, has been indicated to be majorly responsible for its beneficial effects. Oleuropein is a secoiridoid type of phenolic compound and consists of three structural subunits: hydroxytyrosol, elenolic acid, and a glucose molecule. It is also reported to be the chemotaxonomic marker of olive. The oleuropein is reported to possess a number of biological activities including action against dyslipidemia, antiobesity, antidiabetic, antioxidant, antiatherogenic, antihypertensive, antiinflammatory, and hepatoprotective actions. The scientific evidence supports the role of oleuropein as a potential agent against metabolic syndrome. The present review discusses chemistry of oleuropein along with potential role of oleuropein with reference to pathophysiology of metabolic syndrome. Abstract :