Approach to overgrowth syndromes in the genome era. Issue 4 (2nd December 2019)

• Record Type: Journal Article
• Authors: Burkardt, Deepika D.; Tatton‐Brown, Katrina; Dobyns, William; Graham, John M.
• Other Names: Burkardt Deepika guestEditor.; Tatton‐Brown Kate guestEditor.; Dobyns William B. guestEditor.; Graham John guestEditor.
• Is Part Of: American journal of medical genetics. Volume 181:Issue 4(2019)
• Page Start: 483
• Page End: 490
• Publication Date: 2019-12-02
• Subjects: epigenetic regulation -- macrocephaly -- megalencephaly -- overgrowth; Medical genetics -- Periodicals; 616.04205
• DOI: 10.1002/ajmg.c.31757
• Languages: English
• ISSNs: 1552-4868

Abstract

Abstract: This introduction to the special issue of AJMG Part C : Overgrowth Syndromes updates the current understanding of overgrowth syndromes. We clarify the terminology associated with overgrowth, review some common pathways to overgrowth and present a preliminary classification based on currently known genomic and epigenetic mechanisms. We introduce the articles of this issue—new research and reviews of well‐established and recently described overgrowth syndromes of the brain, body or both.