The Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study: baseline participant profile. Issue 1 (7th October 2019)

• Record Type: Journal Article
• Authors: Métral, M; Darling, KEA; Locatelli, I; Nadin, I; Santos, G; Brugger, P; Kovari, H; Cusini, A; Gutbrod, K; Tarr, PE; Calmy, A; Lecompte, TD; Assal, F; Monsch, A; Kunze, U; Stoeckle, M; Schwind, M; Schmid, P; Pignatti, R; Di Benedetto, C; Du Pasquier, R; Cavassini, M
• Other Names: Cavassini Matthias investigator.; Du Pasquier Renaud investigator.; Métral Mélanie investigator.; Simioni Samanta investigator.; Brugger Peter investigator.; Gutbrod Klemens investigator.; Monsch Andreas U. investigator.; Kunze Ursi investigator.; Schneitter Marianne investigator.; Nadin Isaure investigator.; Früh Severin investigator.; Schwind Marc investigator.; Pignatti Riccardo investigator.; Clarke Stefanie investigator.; Assal Frédéric investigator.; Derfuss Tobias investigator.; von Arx Sebastian investigator.; Eisele Günter investigator.; Sacco Leonardo investigator.; Bertschi Manuel investigator.; Hundsberger Thomas investigator.; Du Pasquier Renaud investigator.; Calmy Alexandra investigator.; Lecompte Thanh Doco investigator.; Hauser Christoph investigator.; Cusini Alexia investigator.; Weber Rainer investigator.; Kovari Helen investigator.; Hasse Barbara investigator.; Tarr Philip investigator.; Stoeckle Marcel investigator.; Fux Christoph investigator.; Bernasconi Enos investigator.; Di Benedetto Caroline investigator.; Bruno Alessandra investigator.; Schmid Patrick investigator.; Darling Katharine investigator.; Cavassini Matthias investigator.; Scherrer Alexandra investigator.; Scherrer Alexandra investigator.; Vallet Yannick investigator.; Alves Deolinda investigator.; Locatelli Isabella investigator.; Decosterd Laurent investigator.; Granziera Cristina investigator.; Krueger Gunnar investigator.; Meuli Reto investigator.; Vargas Maria investigator.;
• Is Part Of: HIV medicine. Volume 21:Issue 1(2020)
• Page Start: 30
• Page End: 42
• Publication Date: 2019-10-07
• Subjects: aging -- HIV‐associated neurocognitive disorder -- neurocognitive impairment -- neuropsychological testing; HIV infections -- Treatment -- Periodicals; HIV-positive persons -- Periodicals; HIV infections -- Treatment -- Decision making -- Periodicals; 616.9792
• DOI: 10.1111/hiv.12795
• Languages: English
• ISSNs: 1464-2662

Abstract

Abstract : Objectives: The aim of the study was to examine baseline neurocognitive impairment (NCI) prevalence and factors associated with NCI among patients enrolled in the Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study. Methods: The NAMACO study is an ongoing, prospective, longitudinal, multicentre and multilingual (German, French and Italian) study within the Swiss HIV Cohort Study. Between 1 May 2013 and 30 November 2016, 981 patients ≥ 45 years old were enrolled in the study. All underwent standardized neuropsychological (NP) assessment by neuropsychologists. NCI was diagnosed using Frascati criteria and classified as HIV‐associated or as related to other factors. Dichotomized analysis (NCI versus no NCI) and continuous analyses (based on NP test z ‐score means) were performed. Results: Most patients (942; 96.2%) had viral loads < 50 HIV‐1 RNA copies/mL. NCI was identified in 390 patients (39.8%): 263 patients (26.8%) had HIV‐associated NCI [249 patients (25.4%) had asymptomatic neurocognitive impairment (ANI)] and 127 patients (13%) had NCI attributable to other factors, mainly psychiatric disorders. There was good correlation between dichotomized and continuous analyses, with NCI associated with older age, non‐Caucasian ethnicity, shorter duration of education, unemployment and longer antiretroviral therapy duration. Conclusions: In this large sample of aging people living with HIV with well‐controlled infection in Switzerland, baseline HIV‐associated NCI prevalence, as diagnosed after formal NP assessment, was 26.8%, with most cases being ANI. The NAMACO study data will enable longitudinal analyses within this population to examine factors affecting NCI development and course.