Characterization of the human myocardium by optical coherence tomography. Issue 12 (26th August 2019)

• Record Type: Journal Article
• Authors: Gan, Yu; Lye, Theresa H.; Marboe, Charles C.; Hendon, Christine P.
• Is Part Of: Journal of biophotonics. Volume 12:Issue 12(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-08-26
• Subjects: cardiovascular diseases -- humans -- myocardium -- optical coherence -- tomography; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201900094
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract: Imaging of cardiac tissue structure plays a critical role in the treatment and understanding of cardiovascular disease. Optical coherence tomography (OCT) offers the potential to provide valuable, high‐resolution imaging of cardiac tissue. However, there is a lack of comprehensive OCT imaging data of the human heart, which could improve identification of structural substrates underlying cardiac abnormalities. The objective of this study was to provide qualitative and quantitative analysis of OCT image features throughout the human heart. Fifty human hearts were acquired, and tissues from all chambers were imaged with OCT. Histology was obtained to verify tissue composition. Statistical differences between OCT image features corresponding to different tissue types and chambers were estimated using analysis of variance. OCT imaging provided features that were able to distinguish structures such as thickened collagen, as well as adipose tissue and fibrotic myocardium. Statistically significant differences were found between atria and ventricles in attenuation coefficient, and between adipose and all other tissue types. This study provides an overview of OCT image features throughout the human heart, which can be used for guiding future applications such as OCT‐integrated catheter‐based treatments or ex vivo investigation of structural substrates. Abstract : Optical coherence tomography (OCT) can provide high‐resolution imaging of the human heart valuable for treating cardiovascular disease. However, comprehensive OCT imaging data in the human heart are lacking. This study provides imaging data from a large sample size of human hearts, and qualitative and quantitative imaging features corresponding to a variety of cardiac tissue types are described, providing guidance for future cardiac applications of OCT.