Degradable inorganic/polymer core-shell microspheres for pH-triggered release of indole-3-acetic acid. Issue 5 (23rd March 2020)

• Record Type: Journal Article
• Authors: Zhao, Linlin; Shi, Luqing; Wang, Jing; Zhang, Qiang; Yang, Xinlin; Lu, Yan
• Is Part Of: International journal of polymeric materials. Volume 69:Issue 5(2020)
• Page Start: 317
• Page End: 325
• Publication Date: 2020-03-23
• Subjects: Drug delivery -- distillation-precipitation polymerization -- functional polymer microspheres -- indole-3-acetic acid -- stimuli responsive; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2018.1563087
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: The narrowly dispersed functional silica/poly(di(metacryloylooxy-1-ethoxy) methane- co -acryl amide) (SiO2 /P(DMOEM- co -AAm)) core-shell microspheres were synthesized by distillation precipitation polymerization of DMOEM as a degradable crosslinker and AAm as a functional monomer with the presence of 3-(methacryloxy)propyltrimethoxysilane (MPS) modified silica microspheres as seeds. Indole-3-acetic acid (IAA) can be efficiently loaded into the microspheres with a loading capacity of 37.5% via hydrogen-bonding interaction between the carboxylic acid group of IAA and the amide groups on the surface of SiO2 /P(DMOEM- co -AAm). The loaded IAA can be triggered released by pH due to the presence of pH-responsive crosslinker (DMOEM). Graphical Abstract: