Understanding the basis of medical use of poly-lactide-based resorbable polymers and composites – a review of the clinical and metabolic impact. (2nd October 2019)

• Record Type: Journal Article
• Authors: Vacaras, Sergiu; Baciut, Mihaela; Lucaciu, Ondine; Dinu, Cristian; Baciut, Grigore; Crisan, Liana; Hedesiu, Mihaela; Crisan, Bogdan; Onisor, Florin; Armencea, Gabriel; Mitre, Ileana; Barbur, Ioan; Kretschmer, Winfried; Bran, Simion
• Is Part Of: Drug metabolism reviews. Volume 51:Number 4(2019)
• Page Start: 570
• Page End: 588
• Publication Date: 2019-10-02
• Subjects: Resorbable polymers -- polylactide -- biomedical composites -- resorbable plate -- cranio-maxillofacial osteosynthesis -- safety -- biodegradation -- tissue engineering -- drug delivery; Drugs -- Metabolism -- Periodicals; Pharmacokinetics -- Periodicals; Pharmaceutical Preparations -- metabolism -- Periodicals; 615
• DOI: 10.1080/03602532.2019.1642911
• Languages: English
• ISSNs: 0360-2532

Abstract

Abstract: This review intended to comparatively explain and present the most important medical use and biological impact of poly-lactides and lactide-based composites. The utilization and degradation of compounds based on lactic acid and polylactides is described in detail. Understanding the metabolism and degradation phenomenon and the factors that potentially influence it is key to modulating their properties as well as their characteristics driven from the fabrication procedures and the fields of use. All these are commented according to the clinician's criteria. The current debate on the advantages and shortcomings of various resorbable polymeric materials categories is also analyzed, from the perspective of the users of resorbable polylactide-based biomaterials. The scientific literature comprises either distinct chemical and physical or specific animal or medical description of resorbable materials; so that in compensation, the present review covers all topics for the most appropriate comprehensive update of the reader.