A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8. Issue 98 (22nd November 2019)

• Record Type: Journal Article
• Authors: Nardelli, Francesca; Ghitti, Michela; Quilici, Giacomo; Gori, Alessandro; Luo, Qingqiong; Berardi, Andrea; Sacchi, Angelina; Monieri, Matteo; Bergamaschi, Greta; Bermel, Wolfgang; Chen, Fuxiang; Corti, Angelo; Curnis, Flavio; Musco, Giovanna
• Is Part Of: Chemical communications. Volume 55:Issue 98(2019)
• Page Start: 14777
• Page End: 14780
• Publication Date: 2019-11-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc08518a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5 ) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. Abstract : Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5 ) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.