Facile synthesis of 9H-pyrrolo[1, 2-a]indoles via Brønsted acid catalyzed cascade reactions. Issue 97 (19th November 2019)

• Record Type: Journal Article
• Authors: Xu, Kunhua; Chen, Wenming; Lin, Jin; Chen, Guifang; Wang, Biao; Tian, Xu
• Is Part Of: Chemical communications. Volume 55:Issue 97(2019)
• Page Start: 14613
• Page End: 14616
• Publication Date: 2019-11-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc07228d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A Brønsted acid system promotes the Friedel–Crafts alkenylation/1, 6-addition/condensation cascade reaction of ynones with indoles to access 9 H -pyrrolo[1, 2- a ]indoles. Abstract : An efficient Brønsted acid catalyzed Friedel–Crafts alkenylation/1, 6-addition/condensation cascade reaction has been developed. This protocol enables effective access to various highly functionalized 9 H -pyrrolo[1, 2- a ]indoles in moderate to high yields. Mechanistic studies indicate that the in situ vinylogous reactivity intermediate might be formed in the catalytic system.