Thermoresponsive drug delivery to mitochondria in vivo. Issue 97 (20th November 2019)

• Record Type: Journal Article
• Authors: Ruan, Lifo; Zhou, Mengxue; Chen, Jun; Huang, Hui; Zhang, Jiayu; Sun, Hongyan; Chai, Zhifang; Hu, Yi
• Is Part Of: Chemical communications. Volume 55:Issue 97(2019)
• Page Start: 14645
• Page End: 14648
• Publication Date: 2019-11-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc07538k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Thermoresponsive drug delivery to mitochondria in a mouse model of cancer. Abstract : Mitochondrial targeting of drugs largely relies on delocalized lipophilic cations. Nevertheless, mitochondrial membrane potentials in cancer cells are inconstant, which could compromise stable mitochondrial targeting. Herein, we further validated a mitochondrial temperature-dependent drug delivery strategy in vivo . Thermoresponsive drug delivery to mitochondria may represent a promising strategy for cancer therapy.