Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes. Issue 68 (2nd December 2019)

• Record Type: Journal Article
• Authors: Le, Yi; Yang, Zhisong; Chen, Yumei; Chen, Dongmei; Yan, Longjia; Wang, Zhenchao; Ouyang, Guiping
• Is Part Of: RSC advances. Volume 9:Issue 68(2019)
• Page Start: 39684
• Page End: 39688
• Publication Date: 2019-12-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra08742g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An efficient and practical procedure was developed to prepare 7-azaindole, starting from an o -haloaromatic amine and corresponding terminal alkynes under microwave irradiation and the scope was demonstrated with a number of examples. Abstract : An efficient and practical procedure was developed to prepare 7-azaindole, starting from an o -haloaromatic amine and corresponding terminal alkynes under microwave irradiation and the scope was demonstrated with a number of examples. The valuable features of this procedure included the iron-catalyzed cyclization, short reaction times and convenient operation. Furthermore, iron catalysis is an interesting alternative to homogeneous catalysis for the synthesis of heterocycles.