Il-10 producing T and B cells in allergy. (August 2019)

• Record Type: Journal Article
• Authors: Boonpiyathad, Tadech; Satitsuksanoa, Pattraporn; Akdis, Mübeccel; Akdis, Cezmi A.
• Is Part Of: Seminars in immunology. Volume 44(2019)
• Publication Date: 2019-08
• Subjects: IL-10 -- Treg cells -- Breg cells -- DCreg cells -- ILCreg cells -- Allergen-specific immunotherapy (AIT) -- Immune tolerance -- Immunosuppression; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2019.101326
• Languages: English
• ISSNs: 1044-5323

Abstract

Highlights: Interleukin-10 (IL-10) is an immune regulatory cytokine with suppressor functions on many cells and different types of inflammatory reactions. Allergen-specific immunotherapy (AIT) is the curative treatment of allergic diseases by inducing IL-10-secreting regulatory T and B cells. The allergen-specific regulatory T and B cells secrete IL-10 to suppress type 2 immune responses and allergic inflammation. IL-10-secreting regulatory dendritic cells, T cells and B cells are important for the maintain of clinical immune tolerance against allergens. Other IL-10-secreting cell subsets such as natural killer-cells and innate lymphoid cells are open for future research. Abstract: The molecular and cellular mechanisms of allergen tolerance in humans have been intensively studied in the past few decades. The demonstration of epitope-specific T cell tolerance, particularly mediated by the immune suppressor functions of IL-10 led to a major conceptual change in this area more than 20 years ago. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory of T and B cells, the immune suppressive function of secreted factors, such as IL-10, IL-35, IL-1 receptor antagonist and TGF-β, immune suppressive functions of surface molecules such as CTLA-4 and PD-1, the production IgG4 isotype allergen-specific blocking antibodies, and decreased allergic inflammatory responses by mast cells, basophils, and eosinophils in inflamed tissues. In this review, we explain the importance of the role of IL-10 in allergen tolerance.