IL-10-producing T cells and their dual functions. (August 2019)

• Record Type: Journal Article
• Authors: Bedke, Tanja; Muscate, Franziska; Soukou, Shiwa; Gagliani, Nicola; Huber, Samuel
• Is Part Of: Seminars in immunology. Volume 44(2019)
• Publication Date: 2019-08
• Subjects: IL Interleukin -- TH T helper -- Treg regulatory T cell -- TR1 type1 regulatory T cell -- IFN interferon -- TNF tumor necrosis factor -- APC antigen presenting cell -- DC dendritic cell -- LAG-3 Lymphocyte-activation gene 3 -- CTLA-4 cytotoxic T lymphocyte associated protein 4, Programmed cell death protein 1 -- TIM-3 T-cell immunoglobulin mucin 3; Interleukin-10 -- T-cells -- Immune regulation -- Inflammation; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2019.101335
• Languages: English
• ISSNs: 1044-5323

Abstract

Abstract: Interleukin (IL)-10 is considered a prototypical anti-inflammatory cytokine, which significantly contributes to the maintenance and reestablishment of immune homeostasis. However, this classical view fails to fully describe the pleiotropic roles of IL-10. Indeed, IL-10 can also promote immune responses, e.g. by supporting B-cell and CD8 + T-cell activation. The reasons for these seemingly opposing functions are unclear to a large extent. Recent and previous studies suggest that the cellular source and the microenvironment impact the function of IL-10. However, studies addressing the mechanisms which determine whether IL-10 promotes inflammation or controls it have just begun. This review first summarizes the recent findings on the heterogeneity of IL-10 producing T cells and their impact on the target cells. Finally, we will propose two possible explanations for the dual functions of IL-10.