A Neglected Case of Multifocal Liposarcoma Presented in Five Different Sites in a Syrian Woman: A case report. (2019)

• Record Type: Journal Article
• Authors: Alawad, Ieman; Al-Haj, Ahmad; Ghazal, Ahmad; Ibrahim, Amna; Masri, Ruqaya
• Is Part Of: International journal of surgery case reports. Volume 65(2019)
• Page Start: 262
• Page End: 266
• Publication Date: 2019
• Subjects: Liposarcoma -- Round cell -- Multifocal -- Case report; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2019.10.077
• Languages: English
• ISSNs: 2210-2612

Abstract

Highlights: Complete surgical resection of liposarcoma is central in treatment based on grade. Radiation reduces risk of local recurrence or minimize surgical morbidity in the highly radiosensitive myxoid/round cell liposarcoma group. Chemotherapy is utilized in chemosensitive histologies with metastatic potential. Understanding of the genetic aberrations allows development of targeted therapies for liposarcoma. Abstract: Introduction: Multifocal soft tissue sarcoma is a rare clinical entity occurring in 1 % of patients with extremity soft tissue sarcoma and in 4.5 % of patients with liposarcoma. Multifocal disease may arise either synchronously or metachronously and has been associated with poor prognosis. Case presentation: Herein, we report a rare case of a Syrian woman patient with six different foci of liposarcoma in five sites at the time of diagnosis. Discussion: Liposarcomas are currently classified into four different subtypes based on histologic or genetic analysis according to the World Health Organization (WHO), including cell-differentiated, dedifferentiated, myxoid, and pleomorphic. In the present work, we report a neglected patient with a multicentric round cell liposarcoma in five different sites. Conclusion: Medicine cannot provide much care for these advanced cases of multicentric liposarcoma so far. Therefore, more research should be conducted to improve the ability to manage these entities and to identify potential novel therapies.