Robust chemical circuits. (December 2019)

• Record Type: Journal Article
• Authors: Ellis, Samuel J.; Klinge, Titus H.; Lathrop, James I.
• Is Part Of: Bio systems. Volume 186(2019)
• Publication Date: 2019-12
• Subjects: Nanocomputing -- Molecular programming -- Circuits -- Robustness -- Chemical reaction networks; Biological systems -- Periodicals; Biology -- Periodicals; Biology -- Periodicals; Evolution -- Periodicals; Biologie -- Périodiques; Évolution -- Périodiques; 570
• DOI: 10.1016/j.biosystems.2019.103983
• Languages: English
• ISSNs: 0303-2647

Abstract

Abstract: We introduce a new motif for constructing robust digital logic circuits using input/output chemical reaction networks. These chemical circuits robustly handle adversarial manipulation to their input signals, initial concentrations, rate constants, and measurements. In particular, we show that all Boolean circuits and several sequential circuits enjoy this robustness. Our results complement existing literature in the following three ways: (1) our logic gates read their inputs catalytically which make fanout gates unnecessary; (2) formal requirements and rigorous proofs of satisfaction are provided for each circuit; and (3) robustness of every circuit is closed under modular composition.