Atypical chronic myeloid leukemia BCR-ABL 1 negative: A case report and literature review. (2019)

• Record Type: Journal Article
• Authors: Belkhair, Jihane; Raissi, Abderahim; Elyahyaoui, Hicham; Ameur, Mustapha Ait; Chakour, Mohamed
• Is Part Of: Leukemia research reports. Volume 12(2019)
• Publication Date: 2019
• Subjects: Atypical chronic myeloid leukemia -- World Health Organization -- Myelodysplastic syndroms/myeloproliferative syndroms -- BCR-ABL1 -- Philadelphia chromosome -- Cytology -- Karyotype -- Molecular biology; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2019.100172
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: Atypical chronic myeloid leukemia (aCML), BCR-ABL1 negative is a rare myelodysplastic syndrome/myeloproliferative neoplasm for which no current standard of care exists. The blood smear of patients with aCML showed prominent immature granulocytosis, and granulocytic dysplasia. We admitted a 58-year-old man with splenomegaly, hyperleukocytosis, anemia, and thrombocytopenia; then cytology, cytogenetic and molecular biology analysis of bone morrow were performed and the diagnosis of aCML was made according to 2016 World Health Organization diagnostic criteria. The patient was initially treated by chemotherapy; the patient achieved an aggravation of anemia. This motivated the change of treatment.