Vienna-II ring applicator for distal parametrial/pelvic wall disease in cervical cancer brachytherapy: An experience from two institutions: Clinical feasibility and outcome. (December 2019)

• Record Type: Journal Article
• Authors: Mahantshetty, Umesh; Sturdza, Alina; Naga CH, Pushpa; Berger, Daniel; Fortin, Israel; Motisi, Laura; Schmid, Maximilian P.; Aravindakshan, Dheera; Ghadi, Yogesh; Swamidas, Jamema V.; Chopra, Supriya; Gurram, Lavanya; Nesvacil, Nicole; Kirisits, Christian; Pötter, Richard
• Is Part Of: Radiotherapy and oncology. Volume 141(2019)
• Page Start: 123
• Page End: 129
• Publication Date: 2019-12
• Subjects: Cervical cancer -- Image-guided adaptive brachytherapy -- Vienna II applicator; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2019.08.004
• Languages: English
• ISSNs: 0167-8140

Abstract

Highlights: In locally advanced cervical cancer (LACC) with residual tumor in distal parametrium or pelvic wall disease after concurrent radio-chemotherapy (CCRT) (category II). Brachytherapy is technically challenging. Our report highlights the clinical feasibility and outcome of patients treated at 2 Institutions. BT was delivered using Vienna II BT Applicator (Vienna ring with add on cap) based IGABT. This approach results in optimal outcome and acceptable grade 3 toxicities. Abstract: Purpose: Recent evidence from EMBRACE shows that around 16% patients with locally advanced cervical cancer (LACC) have residual tumor in distal parametrium (DP) and pelvic wall disease (LPW) after concurrent radio-chemotherapy (CCRT). Adequate target coverage with standard brachytherapy approaches represents a challenge. Therefore, we modified the Vienna I applicator with an add-on cap allowing for additional oblique needles into the DP/LPW (Vienna II). We report here the feasibility and clinical outcomes using Vienna II applicator in LACC patients treated in 2 institutions. Methods and materials: 69 patients with residual disease in DP/LPW after CCRT were accrued. FIGO (2009) stage was 26% IIB, 52% III, 15% IVA, 7% IVB (para-aortic nodes). At diagnosis 91% had disease involving DP/LPW. After CCRT, patients underwent image guided adaptive brachytherapy (IGABT) using Vienna II applicator. IGABT details, acute complications, dose volume parameters and clinical outcome variables were compiled and analyzed. Results: Residual DP/LPW disease at BT was found in 90% patients. Median total number of needles were 7 [3–15], oblique 4 [1–7]. Manageable intraoperative utero-vaginal complications occurred in 8 patients and manageable arterial bleeding in 6 patients during removal. Mean distance between tandem and outer contour of CTVHR was 38 mm and mean CTVHR (±SD) volume was 69 ± 32 cm 3 . The mean D 90 CTVHR was 86 ± 7 Gy (EQD2) and mean (±SD) D 2cm 3 (Gy, EQD2) 86 ± 12, 68 ± 7, 68 ± 9 for bladder, rectum and sigmoid respectively. Actuarial LC, PFS, OS at 3/5 years was 76/72%, 56/50%, 62/54% and G3-4 late toxicities ( n = 23) were observed in 14 patients (20%). Conclusions: IGABT using Vienna II applicator allows for appropriate target coverage in tumors extending into DP/LPW at the time of BT. Clinical use is feasible and results in good local control, DFS and OS with moderate rate of acute and late ≥G3 toxicity.