Pathogenic memory plasma cells in autoimmunity. (December 2019)

• Record Type: Journal Article
• Authors: Chang, Hyun-Dong; Tokoyoda, Koji; Hoyer, Bimba; Alexander, Tobias; Khodadadi, Laleh; Mei, Henrik; Dörner, Thomas; Hiepe, Falk; Burmester, Gerd-Rüdiger; Radbruch, Andreas
• Is Part Of: Current opinion in immunology. Volume 61(2019)
• Page Start: 86
• Page End: 91
• Publication Date: 2019-12
• Subjects: Immunology -- Periodicals; Allergy -- Periodicals; Immunology -- Abstracts -- Periodicals; Allergy -- Abstracts -- Periodicals; 616.079
• DOI: 10.1016/j.coi.2019.09.005
• Languages: English
• ISSNs: 0952-7915

Abstract

Highlights: Memory plasma cells are long-lived but require specialized niches for their survival. Memory plasma cells are refractory to conventional immunosuppression. Pathogenic memory plasma cells represent 'roadblocks' to response to conventional therapy. Strategies for (selective) targeting of memory plasma cells are in preclinical and clinical tests.