Second‐line chemotherapy in advanced biliary cancers: A retrospective, multicenter analysis of outcomes. Issue 24 (27th August 2019)

• Record Type: Journal Article
• Authors: Lowery, Maeve A.; Goff, Laura W.; Keenan, Bridget P.; Jordan, Emmet; Wang, Rui; Bocobo, Andrea G.; Chou, Joanne F.; O'Reilly, Eileen M.; Harding, James J.; Kemeny, Nancy; Capanu, Marianela; Griffin, Ann C.; McGuire, Joseph; Venook, Alan P.; Abou‐Alfa, Ghassan K.; Kelley, Robin K.
• Is Part Of: Cancer. Volume 125:Issue 24(2019)
• Page Start: 4426
• Page End: 4434
• Publication Date: 2019-08-27
• Subjects: biliary cancer -- bile duct cancer -- chemotherapy -- cholangiocarcinoma -- gallbladder cancer -- second line; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.32463
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : Background: Although gemcitabine plus platinum chemotherapy is the established first‐line regimen for advanced biliary cancer (ABC), there is no standard second‐line therapy. This study evaluated current practice and outcomes for second‐line chemotherapy in patients with ABC across 3 US academic medical centers. Methods: Institutional registries were reviewed to identify patients who had received second‐line chemotherapy for ABC from April 2010 to March 2015 along with their demographics, diagnoses and staging, treatment histories, and clinical outcomes. Overall survival from the initiation of second‐line chemotherapy (OS2) was estimated with Kaplan‐Meier methods. Results: This study identified 198 patients with cholangiocarcinoma (intrahepatic [61.1%] or extrahepatic [14.1%]) or gallbladder carcinoma (24.8%); 52% received at least 3 lines of systemic chemotherapy. The median OS2 was 11 months (95% confidence interval [CI], 8.8‐13.1 months). The median OS2 for patients with intrahepatic cholangiocarcinoma was 13.4 months (95% CI, 10.7‐17.8 months), which was longer than that for patients with extrahepatic cholangiocarcinoma (6.8 months; 95% CI, 5‐10.6 months) or gallbladder carcinoma (9.4 months; 95% CI, 7.2‐12.3 months; P = .018). The median time to second‐line treatment failure was 2.2 months (95% CI, 1.8‐2.7 months), and it was similar across tumor locations ( P = .60). Conclusions: In this large cohort of patients with ABC treated across 3 academic medical centers after the failure of first‐line chemotherapy, the time to treatment failure on standard therapies was short, although the median OS2 was longer than has been reported previously, and more than half of the patients received additional lines of treatment. This multicenter collaboration represents the largest cohort studied to date of second‐line chemotherapy for ABC and provides a contemporary benchmark for future clinical trials. Abstract : In this large cohort of patients with advanced biliary cancer treated across 3 academic medical centers after the failure of first‐line chemotherapy, the overall survival after second‐line chemotherapy is higher than has been reported previously, and more than half of the patients receive additional lines of treatment. This multicenter collaboration represents the largest cohort studied to date of second‐line chemotherapy for advanced biliary cancer and provides a contemporary benchmark for future clinical trials.