Front Cover: Modulation and Visualization of EF‐G Power Stroke During Ribosomal Translocation (ChemBioChem 23/2019). (8th November 2019)

• Record Type: Journal Article
• Authors: Yin, Heng; Gavriliuc, Miriam; Lin, Ran; Xu, Shoujun; Wang, Yuhong
• Is Part Of: Chembiochem. Volume 20:Number 23(2019)
• Page Start: 2883
• Page End: 2883
• Publication Date: 2019-11-08
• Subjects: antibiotics -- crosslinked EF-G -- force-induced remnant magnetization spectroscopy -- power stroke -- ribosomal translocation -- translocation fidelity; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201900662
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : Power to the finish line : During ribosomal translocation, elongation factor G (EF‐G) produces a significant power stroke that is the main driving force for the ribosome to move forward one codon at a time (top kangaroo). The force is generated through a large change in conformation (green, ribosome large subunit; red, EF‐G). Consequently, when a crosslinker is implemented, only a weak power stroke is generated (bottom kangaroo). Interestingly, the ribosome still moves by one codon at a time, but at a slower rate. More information can be found in the full paper by S. Xu, Y. Wang, et al. on page 2927 in Issue 23, 2019 (DOI: 10.1002/cbic.201900276 ).