The various shades of ER‐phagy. (13th August 2019)

• Record Type: Journal Article
• Authors: Stolz, Alexandra; Grumati, Paolo
• Is Part Of: FEBS journal. Volume 286:Number 23(2019)
• Page Start: 4642
• Page End: 4649
• Publication Date: 2019-08-13
• Subjects: autophagy -- endoplasmic reticulum -- ER‐phagy -- lysosome; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.15031
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : Endoplasmic reticulum (ER) is a large and dynamic cellular organelle. ER morphology consists of sheets, tubules, matrixes, and contact sites shared with other membranous organelles. The capacity of the ER to fulfill its numerous biological functions depends on its continuous remodeling and the quality control of its proteome. Selective turnover of the ER by autophagy, termed ER‐phagy, plays an important role in maintaining ER homeostasis. ER network integrity and turnover rely on specific ER‐phagy receptors, which influence and coordinate alterations in ER morphology and the degradation of ER contents and membranes via the lysosome, by interacting with the LC3/GABARAP family. In this commentary, we discuss general principles and identify the major players in this recently characterized form of selective autophagy, while simultaneously highlighting open questions in the field. Abstract : The endoplasmic reticulum (ER) is a large and dynamic cellular organelle. Its capacity to fulfill the numerous biological functions depends on its continuous remodeling and the quality control of its proteome. Selective turnover of the ER (ER‐phagy) maintains ER homeostasis. ER network integrity and turnover rely on specific ER‐phagy receptors, which influence and coordinate alterations in ER morphology and the degradation of ER contents and membranes via the lysosome.