UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng. Issue 66 (26th November 2019)

• Record Type: Journal Article
• Authors: Zhu, Hailin; Liu, Junli; Lin, Hongqiang; Zhang, Ying; Yang, Na; Zhou, Baisong; Wang, Zhongyao; Chen-Yu Hsu, Alan; Liu, Jinping; Li, Pingya
• Is Part Of: RSC advances. Volume 9:Issue 66(2019)
• Page Start: 38658
• Page End: 38668
• Publication Date: 2019-11-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra06635g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Four previously undescribed ginsenosides, along with five known analogues were isolated from wild ginseng by a UPLC-QTOF-MS-guided fractionation procedure. Abstract : Four previously undescribed ginsenosides, along with five known analogues were isolated from wild ginseng by a UPLC-QTOF-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, HR-ESI-MS). The isolated compounds could significantly inhibit the cigarette smoke extract (CSE)-induced inflammatory reaction in A549 cells. The HDAC2 pathway might be involved in the protective effect against the CSE-mediated inflammatory response in A549 cells.