Trillions and Trillions: Herpes Simplex Virus–1 Hepatitis in an Immunocompetent Adult. (5th November 2019)

• Record Type: Journal Article
• Authors: Ikuta, Kevin; Roychoudhury, Pavitra; Xie, Hong; Mcclurkan, Christopher L; Walkiewicz, Magdalena; Makhsous, Negar; Huang, Meei-Li; Beru, Yodit; Alam, Mariam; Shepherd, Amanda; Lamotte, Eric D; Patel, Kevin; Morris, Amy; Ҫoruh, Başak; Yu, Lei; Bhattacharya, Renuka; Cheng, Rex; Walter, Roland B; Limaye, Ajit P; Lockwood, Christina M; Holland, Steven M; Rakita, Robert M; Koelle, David M; Greninger, Alexander L
• Is Part Of: Open forum infectious diseases. Volume 6:Number 11(2019)
• Publication Date: 2019-11-05
• Subjects: hepatitis -- herpes simplex virus -- host response -- HSV-1 -- HSV hepatitis -- viral evolution; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofz465
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We describe a case of acute liver failure and myopericarditis due to herpes simplex virus–1 (HSV-1) in an immunocompetent adult. We estimate that, at the height of viremia, the patient contained a quantity of HSV-1 virions approaching that of human cells. The patient recovered with acyclovir that was dose-adjusted for neurotoxicity and developed a vigorous anti-HSV-1 T-cell response.