Differences by Sex in Cardiovascular Comorbid Conditions Among Older Adults (Aged 50–64 or ≥65 Years) Receiving Care for Human Immunodeficiency Virus. (3rd May 2019)

• Record Type: Journal Article
• Authors: Frazier, Emma L; Sutton, Madeline Y; Tie, Yunfeng; Fagan, Jennifer; Fanfair, Robyn Neblett
• Is Part Of: Clinical infectious diseases. Volume 69:Number 12(2019)
• Page Start: 2091
• Page End: 2100
• Publication Date: 2019-05-03
• Subjects: aging -- HIV -- sex differences -- cardiovascular -- comorbidity; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciz126
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Background: Differences by sex in cardiovascular comorbid conditions among human immunodeficiency virus (HIV)–infected persons aged 50–64 years have been understudied; even fewer data are available for persons aged ≥65 years. Methods: We used matched interview and medical record abstraction data from the 2009–2012 data cycles of the Medical Monitoring Project, a nationally representative sample of HIV-infected adults in care. We included men and women aged 50–64 and ≥65 years at time of interview. We calculated weighted prevalence estimates and used logistic regression to compute adjusted prevalence differences and 95% confidence intervals (CIs) assessing sex differences in various characteristics and cardiovascular comorbid conditions. Comorbid conditions included overweight/obesity (body mass index ≥25), abnormal total cholesterol level (defined as ≥200 mg/dL), diagnosed diabetes mellitus, or diagnosed hypertension. Results: Of 7436 participants, 89.5% were aged 50–64 years and 10.4% aged ≥65 years, 75.1% were men, 40.4% (95% CI, 33.5%–47.2%) were non-Hispanic black, 72.0% (70.4%–73.6%) had HIV infection diagnosed ≥10 years earlier. After adjustment for sociodemographic and behavioral factors, women aged 50–64 years were more likely than men to be obese (adjusted prevalence difference, 8.4; 95% CI, 4.4–12.3), have hypertension (3.9; .1–7.6), or have high total cholesterol levels (9.9; 6.2–13.6). Women aged ≥65 years had higher prevalences of diabetes mellitus and high total cholesterol levels than men. Conclusions: Cardiovascular comorbid conditions were prevalent among older HIV-infected persons in care; disparities existed by sex. Closer monitoring and risk-reduction strategies for cardiovascular comorbid conditions are warranted for older HIV-infected persons, especially older women. Abstract : Cardiovascular comorbid conditions were prevalent among older persons (aged 50–64 or ≥65 years) in human immunodeficiency virus care, with disparities by sex. Closer monitoring and risk-reduction strategies for these conditions are warranted in this population, especially for women.