P205 Prevalence and risk factors for anxiety and depressive symptoms in children, adolescents and young adults with inflammatory bowel disease. (16th January 2018)

• Record Type: Journal Article
• Authors: van den Brink, G; Stapersma, L; Vlug, L; Rizopolous, D; Bodelier, A; van Wering, H; Hurkmans, P; Stuyt, R; Hendriks, D; van der Burg, J; Utens, E; Escher, J
• Is Part Of: Journal of Crohn's and colitis. Volume 12:Number 1(2018:Jan.)Supplement 1
• Page Start: S202
• Page End: S203
• Publication Date: 2018-01-16
• Subjects: Inflammatory bowel diseases -- Periodicals; 616.344005
• DOI: 10.1093/ecco-jcc/jjx180.332
• Languages: English
• ISSNs: 1873-9946

Abstract

Abstract: Background: Young patients with inflammatory bowel disease (IBD) are at risk for developing anxiety and depression with a 10–50% prevalence rate. This study aims to describe prevalence and severity of anxiety and depressive symptoms in a Dutch cohort of young IBD patients, and identifies demographic and clinical risk factors. Methods: IBD patients ( n = 374; 10–25 years) participating in a randomised controlled trial (ClinicalTrials.gov: NCT02265588) were screened for anxiety, depression and quality of life using validated age-specific questionnaires. Patients with elevated scores for anxiety and/or depression received a psychiatric interview assessing severity. Demographic and clinical characteristics were retrieved from medical charts. Multiple logistic regression analysis was performed to identify risk factors for anxiety and/or depression. Results: Patients (mean age 18.9 years, 44.1% male, Crohn's disease 60.4%) had disease in remission (76%), or mild, moderate and severe disease activity in respectively 19.5%, 2.7% and 2.1%. Psychological symptoms were absent, mild or severe in 52.4%, 35.2% and 12.4% of patients. Elevated symptoms of either anxiety, depression or both were found in respectively 28.6%, 3.0% and 15.9% and did not differ between patients < 18 and >18 years. Active disease was a significant risk factor for depressive symptoms (OR 4.6, p < 0.001). Significant risk factors for anxiety and anxiety and/or depression were female gender (OR 1.7), active disease (OR 1.9) and a shorter disease duration (OR 1.4) (all p < 0.025). Conclusions: Considering the high prevalence of anxiety and depressive symptoms, screening is recommended in young IBD patients. Physicians should be aware that female patients and patients with active disease are the most vulnerable.