White matter and schizophrenia: A meta-analysis of voxel-based morphometry and diffusion tensor imaging studies. (30th December 2017)

• Record Type: Journal Article
• Authors: Vitolo, Enrico; Tatu, Mona Karina; Pignolo, Claudia; Cauda, Franco; Costa, Tommaso; Ando', Agata; Zennaro, Alessandro
• Is Part Of: Psychiatry research. Volume 270(2017)
• Page Start: 8
• Page End: 21
• Publication Date: 2017-12-30
• Subjects: Schizophrenia -- White matter -- Meta-analysis -- Voxel-based morphometry -- Diffusion tensor imaging; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2017.09.014
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: Voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) are the most implemented methodologies to detect alterations of both gray and white matter (WM). However, the role of WM in mental disorders is still not well defined. We aimed at clarifying the role of WM disruption in schizophrenia and at identifying the most frequently involved brain networks. A systematic literature search was conducted to identify VBM and DTI studies focusing on WM alterations in patients with schizophrenia compared to control subjects. We selected studies reporting the coordinates of WM reductions and we performed the anatomical likelihood estimation (ALE). Moreover, we labeled the WM bundles with an anatomical atlas and compared VBM and DTI ALE-scores of each significant WM tract. A total of 59 studies were eligible for the meta-analysis. WM alterations were reported in 31 and 34 foci with VBM and DTI methods, respectively. The most occurred WM bundles in both VBM and DTI studies and largely involved in schizophrenia were long projection fibers, callosal and commissural fibers, part of motor descending fibers, and fronto-temporal-limbic pathways. The meta-analysis showed a widespread WM disruption in schizophrenia involving specific cerebral circuits instead of well-defined regions. Highlights: White matter reductions in schizophrenia involve specific cerebral circuits. Voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) detect some shared WM bundles. Meta-regression analyses found significant effects of age, duration of illness, and gender on several WM bundles. The bundles detected by both methodologies may be the "core tracts" of the WM impairments in schizophrenia. Schizophrenia seems to be characterized by several dysfunctionalities and disconnections of a widespread cerebral network.