Xenorhabdus stockiae KT835471-mediated feasible biosynthesis of metal nanoparticles for their antibacterial and cytotoxic activities. (17th November 2017)

• Record Type: Journal Article
• Authors: Chandrakasan, Gobinath; Seetharaman, PrabuKumar; Gnanasekar, Sathishkumar; Kadarkarai, Murugan; Sivaperumal, Sivaramakrishnan
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 45:Number 8(2017)
• Page Start: 1675
• Page End: 1684
• Publication Date: 2017-11-17
• Subjects: Xenorhabdus stockiae KT835471 -- metal nanoparticles -- X-ray diffraction -- lung cancer -- apoptosis; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2017.1282495
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: In this study, extracellular metabolites of symbiotic bacteria Xenorhabdus stockiae (KT835471) was employed for the synthesis of silver (XsAgNPs) and gold nanoparticles (XsAuNPs). Synthesized NPs were characterized using high throughput instrumentation which confirms the generation of stable, crystalline XsAgNPs and XsAuNPs with the mean size of 14 ± 6 and 14 ± 5, respectively. Further, the NPs exhibits an excellent bactericidal effect against six different pathogens. On the other hand, NPs displayed an outstanding anticancer activity against human lung adenocarcinoma epithelial cells (A549). Therefore, the present study strongly suggests that metal NPs encrusted with functional bio-moieties can be used for different biomedical applications.