Conjugated anionic PEG-citrate G2 dendrimer with multi-epitopic HIV-1 vaccine candidate enhance the cellular immune responses in mice. (17th November 2017)

• Record Type: Journal Article
• Authors: Abdoli, Asghar; Radmehr, Nina; Bolhassani, Azam; Eidi, Akram; Mehrbod, Parvaneh; Motevalli, Fatemeh; Kianmehr, Zahra; Chiani, Mohsen; Mahdavi, Mehdi; Yazdani, Shaghayegh; Ardestani, Mehdi Shafiee; Kandi, Mohammad Reza; Aghasadeghi, Mohammad Reza
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 45:Number 8(2017)
• Page Start: 1762
• Page End: 1768
• Publication Date: 2017-11-17
• Subjects: Epitope -- vaccine -- HIV -- dendrimer -- CpG motif; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2017.1290642
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Multi-epitope vaccines might cause immunity against multiple antigenic targets. Four immunodominant epitopes of HIV-1 genome were used to construct a polytope vaccine, formulated by dendrimer. Two regimens of polytopes mixture with dendrimer were utilized to immunize BALB/c mice. Adjuvants were also used to boost immune responses. The conjugated polytope could arouse significant cellular immune responses ( P < 0.05) and Th1 response showed higher intensity compared to Th2 ( P < 0.05). Our study depicted that conjugated dendrimer with multi-epitopic rHIVtop4 would efficiently induce cell-mediated immune responses and might be considered as promising delivery system for vaccines formulation.