Application of new ZnO nanoformulation and Ag/Fe/ZnO nanocomposites as water-based nanofluids to consider in vitro cytotoxic effects against MCF-7 breast cancer cells. (17th November 2017)

• Record Type: Journal Article
• Authors: Abdolmohammadi, Mohammad Hossein; Fallahian, Faranak; Fakhroueian, Zahra; Kamalian, Mozhgan; Keyhanvar, Peyman; M. Harsini, Faraz; Shafiekhani, Azizollah
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 45:Number 8(2017)
• Page Start: 1769
• Page End: 1777
• Publication Date: 2017-11-17
• Subjects: Modification of surface -- hydrophilic ZnO nanosurface -- breast cancer cell lines MCF-7 -- wide bandgap energy -- normal human fibroblast cell MRC-5 -- synergistic effect -- high trapping states; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2017.1290643
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Novel formulations of nanocomposites derived from ZnO nanoparticles have provided potential biomedical applications as a new strategy for treatment of breast cancer. In this research, two types of ZnO nanomaterials were synthesized by sol–gel hydrothermal process and co-precipitation containing fast quenching and also surface modification methods. The cytotoxic effects on growth of the breast cancer cell lines MCF-7 were evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. Cell viability of the breast cancer cell line MCF-7 was reduced with increasing ZnO nanofluid concentrations at 48 and 72 h of treatment. The IC50 value of MCF-7 cells after 72 h of treatment with the first product ZnO (a) and second one ZnO (c) were measured as 51.02 and 48.63 μg/ml, respectively ( P < 0.05).