Alkyllithium Compounds Bearing Electrophilic Functional Groups: A Flash Chemistry Approach. Issue 12 (14th February 2019)

• Record Type: Journal Article
• Authors: Nagaki, Aiichiro; Yamashita, Hiroki; Hirose, Katsuyuki; Tsuchihashi, Yuta; Yoshida, Jun‐ichi
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 12(2019)
• Page Start: 4027
• Page End: 4030
• Publication Date: 2019-02-14
• Subjects: flow chemistry -- lithium -- microreactors -- nucleophilic addition -- synthetic methods; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201814088
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Flash chemistry based on flow microreactor systems allowed alkyllithiums bearing electrophilic functional groups to be successfully generated and used for subsequent reactions. The series of reactions with high reactivity was achieved by extremely accurate control over residence time in a controlled and selective manner. Abstract : In a flash : Flash chemistry using flow microreactor systems enables the generation and reaction of alkyllithium compounds bearing electrophilic functional groups. High‐resolution control of the residence time is responsible for the successful transformations. Micromixers=M1 and M2, microtube reactors=R1 and R2, LiNp=lithium naphthalenide.