Metal‐Helix Frameworks from Short Hybrid Peptide Foldamers. (25th January 2019)

• Record Type: Journal Article
• Authors: Misra, Rajkumar; Saseendran, Abhijith; Dey, Sanjit; Gopi, Hosahudya N.
• Is Part Of: Angewandte Chemie. Volume 131:Number 8(2019)
• Page Start: 2273
• Page End: 2277
• Publication Date: 2019-01-25
• Subjects: Foldamere -- Helices -- Metallkoordination -- Netzwerke -- Röntgenbeugung; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201810849
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: The potential of structured peptides has not been explored much in the design of metal‐organic frameworks (MOFs). This is partly due to the difficulties in obtaining stable secondary structures from the short α‐peptide sequences. Here we report the design, crystal conformations, coordination site dependent different silver coordinated frameworks of short α, γ‐hybrid peptide 12‐helices consisting of terminal pyridyl moieties and the utility of metal‐helix frameworks in the adsorption of CO2 . Upon silver ion coordination the 12‐helix terminated by the 3‐pyridyl derivatives adopted a 2:2 macrocyclic structure, while the 12‐helix terminated by the 4‐pyridyl derivatives displayed remarkable porous metal‐helix frameworks. Both head‐to‐tail intermolecular H‐bonds of the 12‐helix and metal ion coordination have played an important role in stabilizing the ordered metal‐helix frameworks. The studies described here open the door to design a new class of metal‐organic‐frameworks from peptide foldamers. Abstract : Helikale Polymerisation : Poröse Metall‐Helix‐Gerüste aus kurzen α, γ‐Hybrid‐Peptidfoldameren, terminiert durch metallkoordinierende Bis(pyridyl)‐Liganden und Silberionen, werden beschrieben. Die Ergebnisse zeigen, dass Helix‐Foldamere als Template für das Design neuer Metall‐Helix‐Gerüste verwendet werden können.