Peptoids advance multidisciplinary research and undergraduate education in parallel: Sequence effects on conformation and lipid interactions. Issue 4 (11th January 2019)

• Record Type: Journal Article
• Authors: Jimenez, Christian J.; Tan, Jiacheng; Dowell, Kalli M.; Gadbois, Gillian E.; Read, Cameron A.; Burgess, Nicole; Cervantes, Jesus E.; Chan, Shannon; Jandaur, Anmol; Karanik, Tara; Lee, Jaenic J.; Ley, Mikaela C.; McGeehan, Molly; McMonigal, Ann; Palazzo, Kira L.; Parker, Samantha A.; Payman, Andre; Soria, Maritza; Verheyden, Lauren; Vo, Vivian T.; Yin, Jennifer; Calkins, Anna L.; Fuller, Amelia A.; Stokes, Grace Y.
• Other Names: Kirshenbaum Kent guestEditor.; Zuckerman Ronald N. guestEditor.
• Is Part Of: Biopolymers. Volume 110:Issue 4(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-01-11
• Subjects: chemistry education -- fluorescence spectroscopy -- sequence‐structure relationships -- peptidomimetics -- phospholipid membranes; Biopolymers -- Periodicals; Peptides -- Periodicals; Spectrum analysis -- Periodicals; 572.33
• DOI: 10.1002/bip.23256
• Languages: English
• ISSNs: 0006-3525

Abstract

Abstract: Peptoids are versatile peptidomimetic molecules with wide‐ranging applications from drug discovery to materials science. An understanding of peptoid sequence features that contribute to both their three‐dimensional structures and their interactions with lipids will expand functions of peptoids in varied fields. Furthermore, these topics capture the enthusiasm of undergraduate students who prepare and study diverse peptoids in laboratory coursework and/or in faculty led research. Here, we present the synthesis and study of 21 peptoids with varied functionality, including 19 tripeptoids and 2 longer oligomers. We observed differences in fluorescence spectral features for 10 of the tripeptoids that correlated with peptoid flexibility and relative positioning of chromophores. Interactions of representative peptoids with sonicated glycerophospholipid vesicles were also evaluated using fluorescence spectroscopy. We observed evidence of conformational changes effected by lipids for select peptoids. We also summarize our experiences engaging students in peptoid‐based projects to advance both research and undergraduate educational objectives in parallel. Abstract :