Antibacterial Activity of Polymers: Discussions on the Nature of Amphiphilic Balance. Issue 12 (14th February 2019)

• Record Type: Journal Article
• Authors: Palermo, Edmund F.; Lienkamp, Karen; Gillies, Elizabeth R.; Ragogna, Paul J.
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 12(2019)
• Page Start: 3690
• Page End: 3693
• Publication Date: 2019-02-14
• Subjects: amphiphilic -- antibacterial -- antimicrobial -- biomimetic -- hemolytic; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201813810
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The purpose of this Viewpoint is to discuss the molecular design principles that guide development of synthetic antimicrobial polymers, especially those intended to mimic the structure of host defense peptides (HDPs). In particular, we focus on the principle of "amphiphilic balance" as it relates to some recently developed polyphosphoniums with somewhat atypical structure. We find that the fundamental concept of amphiphilic balance is still applicable to these new polymers, but that the method to achieve such balance is somewhat unique. We then briefly outline the future challenges and opportunities in this field. Abstract : The molecular design principles that guide development of synthetic antimicrobial polymers are discussed with a particular focus on the principle of "amphiphilic balance" as it relates to some recently developed polyphosphonium compounds with somewhat atypical structure. It is found that the fundamental concept of amphiphilic balance is still applicable to these new polymers.