Nucleus‐Targeted Organoiridium–Albumin Conjugate for Photodynamic Cancer Therapy. (21st January 2019) - Zhang, Pingyu
Abstract: An organoiridium–albumin bioconjugate (Ir1‐HSA ) was synthesized by reaction of a pendant maleimide ligand with human serum albumin. The phosphorescence of Ir1‐HSA was enhanced significantly compared to parent complex Ir1 . The long phosphorescence lifetime and high 1 O2 quantum yield of Ir1‐HSA are highly favorable properties for photodynamic therapy. Ir1‐HSA mainly accumulated in the nucleus of living cancer cells and showed remarkable photocytotoxicity against a range of cancer cell lines and tumor spheroids (light IC50 ; 0.8–5 μm, photo‐cytotoxicity index PI=40–60), while remaining non‐toxic to normal cells and normal cell spheroids, even after photo‐irradiation. This nucleus‐targeting organoiridium‐albumin is a strong candidate photosensitizer for anticancer photodynamic therapy. Abstract : Zielsicherer Komplex : Ein auf den Zellkern gerichtetes Organo‐Iridium‐HSA‐Konjugat für die photodynamische Therapie wurde entwickelt. Die Phosphoreszenz eines schwach emittierenden Maleimid‐funktionalisierten Ir‐Komplexes wird bei Konjugation mit humanem Serumalbumin stark erhöht. Das Iridium‐HSA‐Konjugat erzeugt 1 O2 für die photodynamische Therapie bei Bestrahlung mit sichtbarem Licht.