Cuboid Vesicles Formed by Frame‐Guided Assembly on DNA Origami Scaffolds. Issue 6 (30th December 2016)

• Record Type: Journal Article
• Authors: Dong, Yuanchen; Yang, Yuhe Renee; Zhang, Yiyang; Wang, Dianming; Wei, Xixi; Banerjee, Saswata; Liu, Yan; Yang, Zhongqiang; Yan, Hao; Liu, Dongsheng
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 6(2017)
• Page Start: 1586
• Page End: 1589
• Publication Date: 2016-12-30
• Subjects: amphiphiles -- DNA nanotechnology -- frame-guided assembly -- self-assembly; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201610133
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: We describe the use of a frame‐guided assembly (FGA) strategy to construct cuboid and dumbbell‐shaped hetero‐vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small‐molecule surfactants) were guided to form hetero‐vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero‐vesicle assemblies with complex DNA nano‐scaffolds. Abstract : Squaring the circle : A frame‐guided assembly (FGA) strategy has been applied to construct cuboid and dumbbell‐shaped hetero‐vesicles on DNA origami scaffolds. With careful design, different types of amphiphiles have been guided to form hetero‐vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero‐vesicle assemblies with complex DNA nano‐scaffolds.