Cationic polymers for enhancing CpG oligodeoxynucleotides-mediated cancer immunotherapy. (April 2019)

• Record Type: Journal Article
• Authors: Fu, Jingru; Cai, Jia; Ling, Guixia; Li, Anning; Zhao, Jiawei; Guo, Xingjie; Zhang, Peng
• Is Part Of: European polymer journal. Volume 113(2019)
• Page Start: 115
• Page End: 132
• Publication Date: 2019-04
• Subjects: Unmethylated CpG ODNs -- Polycationic biomaterials -- Delivery; AP-1 activator protein 1 -- APC antigen presenting cells -- BNNs boron nitride nanospheres -- CNTs carbon nano-tubes -- CpG ODNs cytosine-phosphate-guanosine oligodeoxynucleotides -- CTL cytotoxic T cells -- DCs dendritic cells -- Dnase DNA enzyme -- ERK extracellular receptor kinase -- Gn Generation n -- IFN-γ interferon-γ -- IFR-7 interferon regulatory factor 7 -- IL-1 interleukin −1 -- IRAK-4 receptor-associated kinase 4 -- JNK c-JUN N-terminal Kinase -- MAPK mitogenactivated protein kinases -- MDCS myeloid dendritic cells -- MW molecular weight -- MyD88 myeloid differentiation factor 88 -- NF-κB nuclear factor kappa B -- NPs Polymer nanoparticles -- NK natural killer -- pDCs plasmacytoid dendritic cells -- PLL Poly-L-lysine -- PEI Polyethylenemine -- PLLD Poly(l-lysine) dendrimer -- ROS reactive oxygen species -- (TAK) 1 transforming growth factor-β-activated kinase -- Th1 T helper 1 -- Th2 T helper 2 -- TLR9 Toll like receptor -- TNF tumor necrosis factor -- TRAF tumor necrosis factor receptor-associated factor -- TRP2 TRP2 tyrosinase related protein 2 -- 95C and 95D cells human lung cancer cell line; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2018.12.044
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Abstract: Unmethylated cytosine-phosphate-guanosine (CpG) oligodeoxynucleotides (ODNs) as an adjuvant can activate innate and adaptive immune responses and simultaneously produce a large number of proinflammatory cytokines and up-regulate costimulatory molecules to treat cancer, allergy, asthma and infectious diseases. Polycationic biomaterials as delivery system can bind to CpG ODNs through electrostatic mechanism and overcome challenging requirements of CpG delivery including low cellular uptake efficiency, short half-life and quick release time and ease to be degraded by DNA enzyme (Dnase). This review provides new developments for the immunizing research of CpG ODNs and also focuses on cationic polymers for enhancing CpG-mediated cancer immunotherapy, together with brief discussions and perspectives for the future research direction.