Dynamic diffusion‐weighted hyperpolarized 13C imaging based on a slice‐selective double spin echo sequence for measurements of cellular transport. Issue 3 (28th October 2018)

• Record Type: Journal Article
• Authors: Zhu, Xucheng; Gordon, Jeremy W.; Bok, Robert A.; Kurhanewicz, John; Larson, Peder E.Z.
• Is Part Of: Magnetic resonance in medicine. Volume 81:Issue 3(2019)
• Page Start: 2001
• Page End: 2010
• Publication Date: 2018-10-28
• Subjects: ADC mapping -- dynamic imaging -- hyperpolarized 13C -- metabolic imaging; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.27501
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: To develop a pulse sequence to dynamically measure the ADC of hyperpolarized substrates during their perfusion, metabolic conversion, and transport. Methods: We proposed a slice‐selective double spin echo sequence for dynamic hyperpolarized 13 C diffusion‐weighted imaging. The proposed pulse sequence was optimized for a high field preclinical scanner through theoretical analysis and simulation. The performance of the method was compared to non‐slice‐selective double spin echo via in vivo studies. We also validated the sequence for dynamic ADC measurement in both phantom studies and transgenic mouse model of prostate cancer studies. Results: The optimized pulse sequence outperforms the traditional sequence with smaller saturation effects on the magnetization of hyperpolarized compounds that allowed more dynamic imaging frames covering a longer imaging time window. In pre‐clinical studies ( N = 8), the dynamic hyperpolarized lactate ADC maps of 6 studies in the prostate tumors showed an increase measured ADC over time, which might be related to lactate efflux from the tumor cells. Conclusions: The proposed sequence was validated and shown to improve dynamic diffusion weighted imaging compared to the traditional double spin echo sequence, providing ADC maps of lactate through time.