EMSQOL-29: Prospective validation of the abbreviated, electronic version of MSQOL-54. (May 2019)

• Record Type: Journal Article
• Authors: Rosato, Rosalba; Testa, Silvia; Bertolotto, Antonio; Scavelli, Francesco; Giovannetti, Ambra M; Confalonieri, Paolo; Patti, Francesco; Chisari, Clara Grazia; Lugaresi, Alessandra; Pietrolongo, Erika; Grasso, Maria Grazia; Rossi, Ilaria; Toscano, Anna; Loera, Barbara; Giordano, Andrea; Solari, Alessandra
• Is Part Of: Multiple sclerosis. Volume 25:Number 6(2019)
• Page Start: 856
• Page End: 866
• Publication Date: 2019-05
• Subjects: Health-related quality of life -- multiple sclerosis -- MSQOL-54 -- electronic migration -- patient reported outcomes -- psychometric assessment; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458518774935
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: We recently devised a shortened version of the 54-item Multiple Sclerosis Quality of Life (MSQOL-54) in paper (MSQOL-29, consisting of 25 items forming 7 subscales and 4 single items, and one filter question for 3 'sexual function' items) and electronic format (eMSQOL-29). Objectives: To prospectively assess eMSQOL-29 psychometric properties, acceptability/equivalence versus MSQOL-29. Methods: Multiple sclerosis (MS) patients ( n = 623; Expanded Disability Status Scale (EDSS) range 0.0–9.0) completed eMSQOL-29, Hospital Anxiety and Depression Scale, Functional Assessment of MS (FAMS), European Quality of life Five Dimensions-3L, and received EDSS and Symbol Digit Modalities Test (SDMT). Equivalence versus MSQOL-29 was assessed in 242 patients (randomized cross-over design). Results: ' Sexual function' items were filtered out by 273 patients (47%). No multi-item scale had floor effect, while five had ceiling effect. Cronbach's alpha range was 0.88–0.90. Confirmatory factor analysis showed good overall fit and the two-factor solution for composite scores was confirmed. Criterion validity was sub-optimal for 'cognitive function' (vs SDMT, r = 0.25) and 'social function' (vs FAMS social function, r = 0.38). eMSQOL-29 equivalence was confirmed and its acceptability was good. Conclusion: eMSQOL-29 showed good internal consistency, factor structure and no floor effect, while most subscales had some ceiling effect. Criterion validity was sub-optimal for two subscales. Equivalence and acceptability were good.