Radiation treatment monitoring with DCE-US in CWR22 prostate tumor xenografts. (June 2019)

• Record Type: Journal Article
• Authors: Arteaga-Marrero, Natalia; Mainou-Gomez, Jose F; Brekke Rygh, Cecilie; Lutay, Nataliya; Roehrich, Dieter; Reed, Rolf K; Olsen, Dag R
• Is Part Of: Acta radiologica. Volume 60:Number 6(2019)
• Page Start: 788
• Page End: 797
• Publication Date: 2019-06
• Subjects: Dynamic contrast-enhanced ultrasound -- DCE-US -- ultrasound -- CWR22 -- prostate -- cancer; Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/0284185118798167
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: Longitudinal monitoring of potential radiotherapy treatment effects can be determined by dynamic contrast-enhanced ultrasound (DCE-US). Purpose: To assess functional parameters by means of DCE-US in a murine subcutaneous model of human prostate cancer, and their relationship to dose deposition and time-frame after treatment. A special focus has been placed to evaluate the vascular heterogeneity of the tumor and on the most suitable data analysis approach that reflects this heterogeneity. Material and Methods: In vivo DCE-US was acquired 24 h and 48 h after radiation treatment with a single dose of 7.5 Gy and 10 Gy, respectively. Tumor vasculature was characterized pixelwise using the Brix pharmacokinetic analysis of the time-intensity curves. Results: Longitudinal changes were detected ( P < 0.001) at 24 h and 48 h after treatment. At 48 h, the eliminating rate constant of the contrast agent from the plasma, kel, was correlated ( P ≤ 0.05) positively with microvessel density (MVD; rτ = 0.7) and negatively with necrosis (rτ = –0.6) for the treated group. Furthermore, Akep, a parameter related to transcapillary transport properties, was also correlated to MVD (rτ = 0.6, P ≤ 0.05). Conclusion: DCE-US has been shown to detect vascular changes at a very early stage after radiotherapy, which is a great advantage since DCE-US is non-invasive, available at most hospitals, and is low in cost compared to other techniques used in clinical practice.