Synaptotagmins: Beyond Presynaptic Neurotransmitter Release. (February 2020)

• Record Type: Journal Article
• Authors: Wu, Xuanang; Hu, Shaoqin; Kang, Xinjiang; Wang, Changhe
• Is Part Of: Neuroscientist. Volume 26:Number 1(2020)
• Page Start: 9
• Page End: 15
• Publication Date: 2020-02
• Subjects: synaptotagmin -- Ca2+ sensor -- neurotransmission -- vesicle recycling -- postsynaptic receptor endocytosis; Neurosciences -- Periodicals; Neurology -- Periodicals; Neurobiology -- Periodicals; 616.8005
• DOI: 10.1177/1073858419844497
• Languages: English
• ISSNs: 1073-8584

Abstract

Synaptotagmins (Syts) are well-established primary Ca 2+ sensors to initiate presynaptic neurotransmitter release. They also play critical roles in the docking, priming, and fusion steps of exocytosis, as well as the tightly coupled exo-endocytosis, in presynapses. A recent study by Awasthi and others (2019) shows that Syt3 Ca 2+ -dependently modulates the postsynaptic receptor endocytosis and thereby promotes the long-term depression (LTD) and the decay of long-term potentiation (LTP). This work highlights the importance of Syt3 in modulating long-term synaptic plasticity and, importantly, extends the function of Syt proteins from presynaptic neurotransmitter release to a new promising postsynaptic receptor internalization.