Association between body composition and osteoarthritis: A systematic review and meta‐analysis. (25th October 2019)

• Record Type: Journal Article
• Authors: Long, Huizhong; Xie, Dongxing; Zeng, Chao; Wei, Jie; Wang, Yilun; Yang, Tuo; Xu, Bei; Qian, Yuxuan; Li, Jiatian; Wu, Ziying; Lei, Guanghua
• Is Part Of: International journal of rheumatic diseases. Volume 22:Number 12(2019)
• Page Start: 2108
• Page End: 2118
• Publication Date: 2019-10-25
• Subjects: body composition -- fat mass -- lean mass -- meta‐analysis -- osteoarthritis; Rheumatology -- Periodicals; Rheumatology -- Asia -- Periodicals; Rheumatology -- Pacific Area -- Periodicals; Rheumatic Diseases -- Periodicals; Connective Tissue Diseases -- Periodicals; Immune System Diseases -- Periodicals; 616.723
• DOI: 10.1111/1756-185X.13719
• Languages: English
• ISSNs: 1756-1841

Abstract

Abstract: Objectives: To examine the association between body composition and osteoarthritis (OA). Methods: An extensive literature review was performed to identify studies that examined the association between body composition and OA. The mean difference (MD), odds ratio (OR), relative risk (RR) and corresponding 95% confidence intervals (CIs) were determined using RevMan statistical software. Results: A total of 19 studies were included. The combined MD showed the fat mass of the subjects with knee OA was higher than that of the control group (MD 4.38, 95% CI: 2.84‐5.92). Both fat mass and fat mass percentage were positively associated with knee OA (ORs ranged from 1.49, 95% CI: 1.15‐1.92, to 2.37, 95% CI: 1.18‐4.74). Similar findings were observed in hip and hand joints as well (ORs ranged from 1.20, 95% CI: 1.08‐1.32, to 1.87, 95% CI: 1.11‐3.15), and such results were also confirmed by most cohort studies of knee and hip OA (RRs ranged from 0.98, 95% CI: 0.95‐1.01, to 3.60, 95% CI: 2.60‐5.00). Lean mass was also positively associated with knee OA (OR 1.48, 95% CI: 1.13‐1.94). However, lean mass percentage was negatively associated with knee OA (OR 0.65, 95% CI: 0.46‐0.92). Conclusions: Both fat mass and fat mass percentage were likely to be risk factors for knee, hip and hand OA. Similarly, lean mass also seemed to be a risk factor for knee OA, while lean mass percentage seemed to be a protective factor.