Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection With Bacteriophages and Antibiotics Combination. (14th March 2019)

• Record Type: Journal Article
• Authors: Nir-Paz, Ran; Gelman, Daniel; Khouri, Ayman; Sisson, Brittany M; Fackler, Joseph; Alkalay-Oren, Sivan; Khalifa, Leron; Rimon, Amit; Yerushalmy, Ortal; Bader, Reem; Amit, Sharon; Coppenhagen-Glazer, Shunit; Henry, Matthew; Quinones, Javier; Malagon, Francisco; Biswas, Biswajit; Moses, Allon E; Merril, Greg; Schooley, Robert T; Brownstein, Michael J; Weil, Yoram A; Hazan, Ronen
• Is Part Of: Clinical infectious diseases. Volume 69:Number 11(2019)
• Page Start: 2015
• Page End: 2018
• Publication Date: 2019-03-14
• Subjects: bacteriophage -- phage -- phage therapy -- antibiotic resistance -- orthopedic infections; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciz222
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: A patient with a trauma-related left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated with bacteriophages and antibiotics. There was rapid tissue healing and positive culture eradication. As a result, the patient's leg did not have to be amputated and he is undergoing rehabilitation.