Implementation of Molecular Surveillance After a Cluster of Fatal Toxoplasmosis at 2 Neighboring Transplant Centers. (19th May 2016)

• Record Type: Journal Article
• Authors: Isa, Flonza; Saito, Kohta; Huang, Yao-Ting; Schuetz, Audrey; Babady, N. Esther; Salvatore, Steven; Pessin, Melissa; van Besien, Koen; Perales, Miguel-Angel; Giralt, Sergio; Sepkowitz, Kent; Papanicolaou, Genovefa A.; Soave, Rosemary; Kamboj, Mini
• Is Part Of: Clinical infectious diseases. Volume 63:Number 4(2016)
• Page Start: 565
• Page End: 568
• Publication Date: 2016-05-19
• Subjects: toxoplasmosis -- stem cell transplant -- reactivation -- T-cell depleted -- CD34+ selected; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciw330
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract : After a cluster of fatal toxoplasmosis among stem cell transplant recipients at 2 hospitals, surveillance with polymerase chain reaction (PCR) (blood) was instituted. Rate of reactivation among seropositive recipients was 2.2 and 16%. Parasitemia was successfully managed with preemptive treatment. For seropositive recipients unable to take prophylaxis, toxoplasma PCR surveillance should be routinely performed.