Dietary poultry intake and the risk of stroke: A dose–response meta-analysis of prospective cohort studies. (February 2018)

• Record Type: Journal Article
• Authors: Mohammadi, Hamed; Jayedi, Ahmad; Ghaedi, Ehsan; Golbidi, Danial; Shab-bidar, Sakineh
• Is Part Of: Clinical nutrition ESPEN. Volume 23(2018)
• Page Start: 25
• Page End: 33
• Publication Date: 2018-02
• Subjects: Poultry intake -- Stroke risk -- Meta-analysis -- Dose–response; Nutritionally induced diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; 616.39005
• DOI: 10.1016/j.clnesp.2017.11.001
• Languages: English
• ISSNs: 2405-4577

Abstract

Summary: Background & aims: We performed a meta-analysis to illuminate and quantify the potential relationship between poultry intake and risk of stroke through summarizing available evidence using a dose–response meta-analysis of prospective cohort studies. Methods: Pertinent prospective cohort studies attained using electronic searches through PubMed, and Scopus up to September 25th, 2017. Relative risks (RR) s with corresponding 95% confidence intervals (CIs) of the highest versus the lowest for cohort studies were evaluated using DerSimonian and Laird random-effects models to find combined RRs. We also assessed the dose–response effect of this relationship. Results: A total of 7 studies involving 354 718 participants were met inclusion criteria. The pooled RR of total stroke risk was [RR = 0.92 95% CI, 0.82, 1.03, I 2 = 19.8%, Pheterogeneity = 0.28] for the highest versus lowest categories of poultry intake. Subgroup analysis showed an inverse associations for the US people [RR = 0.86 95% CI, 0.77, 0.95, I 2 = 0.0%, Pheterogeneity = 0.38] and women [RR = 0.83, 95% CI, 0.72, 0.93, I 2 = 0.0%, Pheterogeneity = 0.63]. We did not obtain any significant association in the subtypes of strokes with highest versus lowest poultry intake [Ischemic stroke (RR = 0.91; 95% CI: 0.79, 1.02, I 2 = 0.0%, p = 0.93), Hemorrhagic (RR = 0.82; 95% CI: 0.59, 1.04, I 2 = 20.5%, Pheterogeneity = 0.28)]. One serving per week increment in poultry intake was not associated with the risk of stroke (RR: 1.00, 95% CI: 0.96, 1.03, I 2 = 69.0%, Pheterogeneity = 0.004). Nonlinear dose–response meta-analysis showed lower risk of stroke at consumption ∼1 serving/week. Conclusion: Our meta-analysis revealed that poultry intake is not associated with total stroke risk; furthermore, an inverse relationship in US population and females must be interpreted with caution.