A135 INCIDENCE OF SUICIDE IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS. (1st March 2018) - Zhang, C
Abstract: Background: Patients with inflammatory bowel disease (IBD) have higher incidence of psychosocial disorders including depression. As suicide is the most severe manifestation of depression, we sought to identify if patients with IBD have a higher incidence of suicide through a systematic review/meta-analysis. Aims: To determine the incidence of suicide in IBD and to determine if patients with IBD were more likely to die from suicide compared to control. Methods: Systematic literature search for articles using EMBASE and MEDLINE was conducted to identify studies investigating suicide in IBD. We included studies reporting expected number of death or standarized mortality ratio (SMR) for suicide in IBD. Meta-analysis for Crohns disease and ulcerative colitis was conducted separately, as well as combined. Results: Seven cohort studies were identified through our search strategy and were included in our systematic review/meta-analysis. In our analysis, the SMR for suicide in patients with IBD for all studies included was 1.20 (95% CI 0.94–1.54). The overall pooled SMR for CD and UC were 1.36 (95% CI 0.98–1.88) and 1.16 (95% CI 0.8–1.69) respectively. Conclusions: Patients with Crohn's disease and ulcerative colitis may have an increased risk of suicide. These results highlight the importance physicians must place on ensuring the mental health of patients with IBD is both assessed and treated appropriately. Funding Agencies: None